I was using Coda to do web development, primarily because of the simple interface, nice Panic Sans font and integrated FTP and Subversion support. I normally just use TextWrangler for Dojo Core development.
Komodo Edit has been mentioned in the Dojo community before as a nice option particularly for doing Dojo development, but I can get severe tunnel-vision, so it was not until recently that really tried out Komodo Edit.
After I changed the key bindings to use the normal OS X COMMAND+] and COMMAND+[ for multi-line indenting, I was ready to go!
As Bespin comes along, I can see it as my next developer tool upgrade, particularly since FTP support has been implicitly needed for some of my projects. With Bespin, I might be able to edit directly on the server.
For now I am enjoying the bump in productivity with Komodo Edit. Thanks ActiveState for making a nice tool available for free!